Protein-kinase-C-related kinases (PRKs) are part of the lipid-regulated protein kinases (PKC) which also include liver PAK & PKN. Human PRK1 and PRK2 share structurally similar catalytic domains, but less similar N-terminal regulatory regions suggesting different regulatory domain functions. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. Additionally, the serine-threonine kinase PRK2 can be specifically cleaved by casp

PDLIM1 is a cytoskeletal protein that may act as an adapter that brings other proteins to the cytoskeleton. PDLIM1 is strongly expressed in the heart $nand skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung, and minimally expressed in liver, thymus, kidney, prostate and pancreas. $nIt is not found in the brain, testis, ovary, and peripheral blood leukocytes.

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]